Development of oral strip for Loratadine and in vitro evaluation

Loratadine is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. The present work was aimed to develop of Loratadine using HPMC E15 LV PREMIUM as film forming polymer, glycerin as a plasticizer and tween 80 as a surfactant. The strips were evaluated for thickness, tensile strength, % elongation, disintegration time and in vitro drug release. A trial and error approach was used in present study for optimization. Oral strip containing HPMC E15 LV PREMIUM (190 mg), tween 80 (15% of polymer) and glycerin (20% of polymer) has given the maximum in vitro drug release and imparts good transparency. A satisfactory result in the strip was exhibited in the way of in vitro release that came in 20 minutes. The drug excipients compatibility study showed that there were no interaction between drug and excipients. Stability study of the optimized formulation showed that the strips were stable at accelerated environmental conditions. Before, the DSC data showed no crystalline form but after 1 month short term, accelerated stability study showed that there was partial crystallization but no change in in vitro dissolution study. So it was concluded that the prepared dosage form was suitable for oral drug delivery.